Basic Information
| LncRNA/CircRNA Name | SOX2 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Ewing sarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | wing`s sarcoma cell lines (SK-NEP-1, SK-ES-1) , Ewing`s sarcoma tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | SOX2OT was identified to be up-regulated in Ewing`s sarcoma tissue and cells. In vitro, SOX2OT knockdown suppressed Ewing`s sarcoma cells proliferation and invasion, and triggered apoptosis. In vivo xenograft assays, SOX2OT knockdown significantly inhibited Ewing`s sarcoma growth. With the help of bioinformatics analysis and luciferase assay, SOX2OT was validated to harbor miR-363, acting as miRNA sponge or competing endogenous RNA (ceRNA). Furthermore, FOXP4 was validated to be the target protein of miR-363. Western blot and RT-PCR confirmed that SOX2OT was positively correlated with FOXP4 protein via sponging miR-363, forming a negative cascade regulation. |
| Pubmed ID | 31312393 |
| Year | 2019 |
| Title | LncRNA SOX2 overlapping transcript acts as a miRNA sponge to promote the proliferation and invasion of Ewing`s sarcoma |
External Links
| Links for SOX2 | GenBank HGNC NONCODE |
| Links for Ewing sarcoma | OMIM COSMIC |