Basic Information
| LncRNA/CircRNA Name | SOX21-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:94712716-94716246 |
| Ensemble | ENSG00000227640 |
| Refseq | NR_046514 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | cell lines(MCF-10A, MDA-MB-231, BT-549, MDA-MB-436,MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | SOX21-AS1 was found to bind with miR-520a-5p. Besides, ORMDL3 was identified as a downstream target of miR-520a-5p, and the suppressed ORMDL3 expression induced by silenced SOX21-AS1 could be restored by miR-520a-5p inhibition. |
| Pubmed ID | 32277517 |
| Year | 2020 |
| Title | Long Noncoding RNA SOX21-AS1 Regulates the Progression of Triple-Negative Breast Cancer Through Regulation of miR-520a-5p/ORMDL3 Axis |
External Links
| Links for SOX21-AS1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |