Basic Information
| LncRNA/CircRNA Name | SOX21-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:94712716-94716246 |
| Ensemble | ENSG00000227640 |
| Refseq | NR_046514 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | nephroblastoma tissues and corresponding adjacent normal tissues, The nephroblastoma cell lines (WiT49 and WT-CLS1) and normal human 99 embryonic kidney cell line (HEK293) |
| Expression Pattern | up-regulated |
| Function Description | SOX21-AS1 expression was elevated in nephroblastoma tissues and cell lines compared with adjacent normal tissues and normal human embryonic kidney cell line, respectively. Moreover, we observed nephroblastoma patients with large tumor size, advanced National Wilms Tumor Study (NWTS) stage or unfavorable histopathological type, and patients that had higher SOX21-AS1 expression levels than nephroblastoma patients with small tumor size, early NWTS stage or favorable histopathological type. The in vitro studies suggested that knockdown of SOX21-AS1 suppressed nephroblastoma cell proliferation and colony formation, and induced cell-cycle arrest through up-regulating p57 expression. |
| Pubmed ID | 30992391 |
| Year | 2019 |
| Title | SOX21-AS1 Is Associated With Clinical Stage and Regulates Cell Proliferation in Nephroblastoma |
External Links
| Links for SOX21-AS1 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |