Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis? | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | PCR, Western blot |
| Sample | bladder cancer tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | SOX2OT was mainly distributed in the cytoplasm and positively regulated SOX2 expression by sponging miR-200c. SOX2 overexpression reversed the SOX2OT silencing-induced inhibition of the BCSC stemness phenotype. |
| Pubmed ID | 32019566 |
| Year | 2020 |
| Title | Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2 |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |