Basic Information
| LncRNA/CircRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | LSCC tissues |
| Expression Pattern | up-regulated |
| Function Description | In conclusion, eight out of the nine tested genes were recurrently over-expressed, but SOX2 and SOX2OT were the most consistently highly over-expressed and thus are the best candidates to be driver genes of 3q26.3 amplifications. |
| Pubmed ID | 20126410 |
| Year | 2010 |
| Title | SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. |
External Links
| Links for SOX2OT | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |