Basic Information
| LncRNA/CircRNA Name | SOX2-OT |
| Synonyms | NA |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | cell lines (NP69,TU-177, M4E, AMC-HN-8 and TU686) |
| Expression Pattern | up-regulated |
| Function Description | SOX2-OT silencing markedly promoted apoptosis and suppressed the proliferation, migration and invasion of TU-177 cells. A dual-luciferase reporter assay revealed that miR-654 was a direct target of SOX2-OT. Moreover, downregulation of miR-654 could attenuate cell apoptosis and accelerate cell proliferation, migration and invasion in TU-177 cells. In summary, the present study reported that knockdown of SOX2-OT could suppress cell proliferation, migration and invasion, and induce apoptosis in laryngeal cancer by targeting miR-654. |
| Pubmed ID | 32266028 |
| Year | 2020 |
| Title | lncRNA SOX2-OT Regulates Laryngeal Cancer Cell Proliferation, Migration and Invasion and Induces Apoptosis by Suppressing miR-654 |
External Links
| Links for SOX2-OT | GenBank HGNC NONCODE |
| Links for laryngeal cancer | OMIM COSMIC |