Basic Information
| LncRNA/CircRNA Name | SOX2-OT |
| Synonyms | NA |
| Region | GRCh38_3:180989762-181836880 |
| Ensemble | ENSG00000242808 |
| Refseq | NR_004053 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qRT-PCR, RIP etc. |
| Sample | human NPC cell lines (5-8F, NPC-TW01, C666-1,SUNE1) |
| Expression Pattern | up-regulated |
| Function Description | SOX2-OT was notably elevated in NPC samples and cells. Further, a high expression level of SOX2-OT was correlated with poor clinical outcomes of NPC. Knockdown of SOX2-OT repressed cell proliferation, arrested cell cycle, facilitated cell apoptosis, and inhibited cell metastasis of NPC.miR-146b-5p was found to directly bind to SOX2-OT, which mediated the role of SOX2-OT in NPC tumorigenesis. In addition, HNRNPA2B1 was a target of miR-146b-5p and SOX2-OT modulated the expression of HNRNPA2B1 through competitively binding to miR-146b-5p. At last, SOX2-OT regulated NPC progression by targeting miR-146b-5p/HNRNPA2B1 pathway, which may provide more innovative targets for the treatment of patients with NPC. |
| Pubmed ID | 31099048 |
| Year | 2019 |
| Title | LncRNA SOX2-OT regulates proliferation andmetastasis of nasopharyngeal carcinoma cells through miR-146b-5p/ HNRNPA2B1 pathway |
External Links
| Links for SOX2-OT | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |