Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | Sprouty4-Intron 1 |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot analysis |
| Sample | melanoma cell lines (A375, A875) and normal (fibroblast-like) skin cell lines (TE 353.SK) |
| Expression Pattern | up-regulated |
| Function Description | PRY4-IT1 level was upregulated in melanoma cells lines compared to the normal skin cells. low-expression of SPRY4-IT1 impeded cell proliferation, invasion, migration, and epithelial-mesenchymal transition. |
| Pubmed ID | 31933852 |
| Year | 2019 |
| Title | Interference From LncRNA SPRY4-IT1 Restrains the Proliferation, Migration, and Invasion of Melanoma Cells Through Inactivating MAPK Pathway by Up-Regulating miR-22-3p |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |