Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | The cervical cancer cell lines (HeLa and CaSki) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1?was up-regulated in CC cell lines. Knockdown of?SPRY4-IT1?significantly inhibited CC cells migration and invasion?in vitro?and?in vivo?Moreover, knockdown of?SPRY4-IT1?significantly suppressed the epithelial-mesenchymal transition (EMT) of CC by increased E-cadherin expression and decreased the N-cadherin and vimentin expression. Mechanically,?SPRY4-IT1?could directly bind to?miR-101-3p?and effectively act as a competing endogenous RNA (ceRNA) for?miR-101-3p?to regulate the expression of the target gene?ZEB1 |
| Pubmed ID | 31092700 |
| Year | 2019 |
| Title | Long Non-Coding RNA?SPRY4-IT1?Promotes Epithelial-Mesenchymal Transition of Cervical Cancer by Regulating the miR-101-3p/ZEB1 Axis |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |