Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | cell lines (SKBR-3, MCF-7, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | We found that lncRNA SPRY4-IT1 was highly expressed in breast cancer cells. SPRY4-IT1 promotes the ability of proliferation, migration, invasion, cell cycle and apoptosis in breast cancer cells in vitro. |
| Pubmed ID | 30104400 |
| Year | 2018 |
| Title | The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1. |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |