Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | GBC tissues, cell lines (EH-GB1, GBC-SD, SGC-996, and NOZ) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1 was upregulated in GBC tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited GBC cell proliferation. Furthermore, inhibitory effects of SPRY4-IT1 on cell migration and invasion were partly associated with EMT process. |
| Pubmed ID | 27902971 |
| Year | 2017 |
| Title | Long non-coding RNA SPRY4-IT1 promotes gallbladder carcinoma progression. |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |