Basic Information
| LncRNA/CircRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA |
| Ensemble | ENSG00000281881 |
| Refseq | NR_131221 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (AGS, BGC-823, HGC-27, SGC-7901, MGC80-3, MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1 expression was elevated in GC tissues and cell lines, and SPRY4-IT1 levels were highly positively correlated with tumor size, invasion depth, distant metastasis, TNM stage, and reduced overall survival (OS) and disease-free survival (DFS). SPRY4-IT1 may regulate the proliferation, migration, and invasion ability of GC cells, partially through regulation of cyclin D1, MMP2, and MMP9 expression. |
| Pubmed ID | 25835973 |
| Year | 2015 |
| Title | Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. |
External Links
| Links for SPRY4-IT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |