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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Western blot
Sample	hepatocellular carcinoma tissues, cell lines (MHCC97L, MHCC97H, HepG2 and SMMC7721, HL7702)
Expression Pattern	up-regulated
Function Description	high expression of SPRY4-IT1 was associated with poor 5-year overall survival in the HCC patient cohort.the expression of SPRY4-IT1 was significantly correlated with TNM stage in HCC patients. knock-down of SPRY4-IT1 suppressed cell proliferation, colony formation, cell invasion and migration in HCC cells.knock-down of SPRY4-IT1 induced cell cycle arrest at G0/G1 phase and induced apoptosis. knock-down of SPRY4-IT1 also suppressed the mRNA and protein expression of estrogen-related receptor a (ERRa).knock-down of ERRa inhibited cell proliferation, colony formation, cell invasion and migration in HCC cells. More importantly, ERRa overexpression antagonized the effects of SPRY4-IT1 knock-down on cell proliferation, colony formation, cell invasion and migration in HCC cells.
Pubmed ID	29214989
Year	2017
Title	Long non-coding RNA SPRY4-IT1 promotes development of hepatic cellular carcinoma by interacting with ERRa and predicts poor prognosis.

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