Basic Information
| LncRNA/CircRNA Name | SRA |
| Synonyms | SRA1, SRA, SRAP, STRAA1, pp7684 |
| Region | GRCh38_5:140537340-140558252 |
| Ensemble | ENSG00000213523 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | breast cancer tissues |
| Expression Pattern | differential expression |
| Function Description | Subgroup analysis showed that SRA expression was similar in ER+/PR+ (median = 65.5, n = 8) and in ER-/PR- (median = 94.6, n = 5) tumors. Interestingly, SRA expression in these two subgroups was significantly lower than that observed in ER+/PR- (median = 156.4, n = 6) and ER-/PR+ (median = 144.8, n = 8) tumors. A variant form of SRA, presenting a deletion of 203 bp within the SRA core sequence, was also observed in breast tumor tissues. The relative expression of this new SRA isoform correlated with tumor grade. |
| Pubmed ID | 10485452 |
| Year | 1999 |
| Title | Expression of the steroid receptor RNA activator in human breast tumors. |
External Links
| Links for SRA | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |