Basic Information
| LncRNA/CircRNA Name | lncRNA-SRA1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical squamous cell carcinoma |
| ICD-0-3 | C53 |
| Methods | qPCR |
| Sample | HPV-negative human cervical squamous cell carcinoma cell line C-33 A, blood |
| Expression Pattern | down-regulated |
| Function Description | plasma SRA1 was downregulated in HPV-negative CSCC patients but not in HPV-positive CSCC patients comparing to healthy females. Downregulated SRA1 distinguished HPV-negative CSCC patients from HPV-positive CSCC patient and healthy females. In HPV-negative CSCC patients, miR-9 was upregulated and inversely correlated with SRA1. In HPV-negative CSCC cells, SRA1 overexpression caused the downregulated miR-9, while miR-9 overexpression failed to affect SRA1. Moreover, SRA1 overexpression caused decreased, while miR-9 overexpression caused increased proliferation, migration and invasion rates of cancer cells. In addition, miR-9 overexpression attenuated the effects of SRA1 overexpression. |
| Pubmed ID | 31371629 |
| Year | 2019 |
| Title | LncRNA SRA1 is downregulated in HPV-negative cervical squamous cell carcinoma (CSCC) and regulates cancer cell behaviors |
External Links
| Links for lncRNA-SRA1 | GenBank HGNC NONCODE |
| Links for cervical squamous cell carcinoma | OMIM COSMIC |