Basic Information
| LncRNA/CircRNA Name | SRHC |
| Synonyms | LINC01018, SRHC |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HCC tissues, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) |
| Expression Pattern | down-regulated |
| Function Description | We found that a lower SRHC expression level was significantly more frequent in tissues with a high serum a-fetoprotein level and a low degree of differentiated tumors. Furthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation. |
| Pubmed ID | 25512078 |
| Year | 2014 |
| Title | Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma. |
External Links
| Links for SRHC | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |