Basic Information
| LncRNA/CircRNA Name | SSTR5-AS1 |
| Synonyms | somatostatin receptor 5 antisense RNA 1 |
| Region | GRCh38_16:1064093-1078731 |
| Ensemble | ENSG00000261713 |
| Refseq | NR_027242 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | gemcitabine | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, Western blot, RIP |
| Sample | GBC tissues,GBC-SD, SGC-996 and NOZ cells |
| Expression Pattern | up-regulated |
| Function Description | SSTR5-AS1 is significantly increased in GBC samples and cell lines, especially in gemcitabine-resistant cell lines, and higher SSTR5-AS1 expression was correlated with poorer overall survival rate in GBC patients. Our data revealed that upregulated SSTR5-AS1 facilitates gemcitabine resistance via inhibiting apoptosis. Knockdown of SSTR5-AS1 sensitized drug resistant GBC cells to gemcitabine in vitro and strongly inhibited xenografts formed by drug resistant GBC cells in vivo. |
| Pubmed ID | 31810606 |
| Year | 2020 |
| Title | Long Non-Coding RNA SSTR5-AS1 Facilitates Gemcitabine Resistance via Stabilizing NONO in Gallbladder Carcinoma |
External Links
| Links for SSTR5-AS1 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |