Basic Information
| LncRNA/CircRNA Name | STXBP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:146841901-147204614 |
| Ensemble | ENSG00000233452 |
| Refseq | NR_034115 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Human CC cell lines (C33A, MS751, SiHa, HeLa, ME-180, and CaSki) and normal immortalized cervical epithelial cell line (NC104), CC tissues and adjacent normal tissues |
| Expression Pattern | down-regulated |
| Function Description | the expression of STXBP5-AS1 and PTEN was reduced while miR-96-5p expression was upregulated in CC. STXBP5-AS1 overexpression significantly reduced CC cells proliferation and invasion ability by suppressing miR96-5p expression. MiR-96-5p promoted CC cells progression via regulating PTEN expression. Furthermore, STXBP5-AS1 was identified as a ceRNA to upregulate PTEN via sponging miR-96-5p in CC |
| Pubmed ID | 31212131 |
| Year | 2019 |
| Title | LncRNA STXBP5-AS1 suppressed cervical cancer progression via targeting miR-96-5p/PTEN axis |
External Links
| Links for STXBP5-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |