Basic Information
| LncRNA/CircRNA Name | SVUGP2 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | A normal human bronchial epithelial cell line 16HBE, an NSCLC squamous carcinomas cell line SK-MES-1, and three NSCLC adenocarcinoma cell lines A549, SPC-A1 and NCIH1975, NSCLC tissues, adjacent non-tumour tissues |
| Expression Pattern | down-regulated |
| Function Description | lncRNA-SVUGP2 was depressed in NSCLC tissues and cells. Overexpression of lncRNA-SVUGP2 depressed proliferation, induced apoptosis, and suppressed migration and invasion of A549 and H1975 cells. In addition, lncRNA-SVUGP2 was repressed by EZH2 and was inversely correlated with EZH2 levels in H1975 cells. Repression of lncRNA-SVUGP2 potentially participated in the oncogenic function of EZH2. Besides, overexpression of lncRNA-SVUGP2 depressed the briskness of Wnt/b-catenin signal in H1975 cells. |
| Pubmed ID | 31401873 |
| Year | 2019 |
| Title | Repression of lncRNA-SVUGP2 mediated by EZH2 contributes to the development of non small cell lung cancer via brisking Wnt/b-catenin signal |
External Links
| Links for SVUGP2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |