Basic Information
| LncRNA/CircRNA Name | TBULC |
| Synonyms | TGF? Upregulated lncRNA in Lung Cancer |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-qPCR |
| Sample | NSCLC tumors and adjacent normal tissues,NSCLC cell lines (A549 and H226) |
| Expression Pattern | up-regulated |
| Function Description | Stimulation with TGF? in NSCLC cell lines significantly upregulated the expression level of the nuclear-localized lncRNA TBULC.Knockdown of TBULC significantly suppressed the invasion and migration of NSCLC cells, and overexpression of TBULC had the opposite effects. The TGF?-induced lncRNA TBULC was upregulated in NSCLC and promoted the invasion and migration of NSCLC cells. |
| Pubmed ID | 31921623 |
| Year | 2020 |
| Title | The TGF?-Induced Long Non-coding RNA TBULC Promotes the Invasion and Migration of Non-small Cell Lung Cancer Cells and Indicates Poor Prognosis |
External Links
| Links for TBULC | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |