Basic Information
| LncRNA/CircRNA Name | TCL6 |
| Synonyms | NA |
| Region | GRCh38_14:95650498-95679833 |
| Ensemble | ENSG00000187621 |
| Refseq | NR_028288 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot |
| Sample | HCC tissues,cell lines |
| Expression Pattern | down-regulated |
| Function Description | TCL6 was downregulated while microRNA-106a-5p (miR-106a-5p) was upregulated in HCC cell??ines.TCL6 as a tumor-suppressive lncRNA regulates PI3K/AKT signaling pathway via directly binding to miR-106a-5p in HCC. |
| Pubmed ID | 32020591 |
| Year | 2020 |
| Title | Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway |
External Links
| Links for TCL6 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |