Basic Information
| LncRNA/CircRNA Name | TCL6 |
| Synonyms | TCL6, TNG1, TNG2 |
| Region | GRCh38_14:95650498-95679833 |
| Ensemble | ENSG00000187621 |
| Refseq | NR_028288 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Microarray, qPCR, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | ccRCC tissues, cell lines (786-0 and Caki-1) |
| Expression Pattern | down-regulated |
| Function Description | To validate the microarray data, we examined the expression of these three lncRNAs in 71 ccRCC and adjacent normal renal tissue samples. Decreased expression of three lncRNAs (ENSG00000177133, TCL6, and ENSG00000244020) was observed in ccRCC compared to adjacent normal tissue. Overexpression of TCL6 inhibited ccRCC cell proliferation and promoted apoptosis. |
| Pubmed ID | 27494890 |
| Year | 2016 |
| Title | Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma. |
External Links
| Links for TCL6 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |