Basic Information
| LncRNA/CircRNA Name | TFAP2A-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:10409340-10416446 |
| Ensemble | ENSG00000229950 |
| Refseq | NR_033910 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | BC tissues ,cell lines(MCF-10A,MCF-7, MDA-MB-231, MDA-MB-435, T47D, SKBR-3 ) |
| Expression Pattern | up-regulated |
| Function Description | Real-time PCR (qRT-PCR) assay was performed to detect the relative mRNA expression of TFAP2A-AS1 and miR-933. Flow cytometry analysis, CCK-8 assay, and Transwell assay were applied to detect the effects of TFAP2A-AS1 overexpression on cell cycle, apoptosis, viability, and invasion of BC cells. |
| Pubmed ID | 30768589 |
| Year | 2019 |
| Title | Long Non-Coding RNA TFAP2A-AS1 Inhibits Cell Proliferation and Invasion in Breast Cancer via miR-933/SMAD2. |
External Links
| Links for TFAP2A-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |