Basic Information
| LncRNA/CircRNA Name | TGFB2-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:218344196-218345678 |
| Ensemble | ENSG00000232480 |
| Refseq | NR_046268 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , in vitro knockdown etc. |
| Sample | hepatocellular carcinoma tumor and normal tissues ,human HCC cell line HepG2 cells |
| Expression Pattern | up-regulated |
| Function Description | TGFB2-AS1 was remarkably increased in HCC tissues and exhibited a potential predictive marker for HCC.Besides, higher expression of TGFB2-AS1 in HCC tissues was identified as being positively associated with advanced tumor and disease stage.Downregulation of TGFB2-AS1 expression significantly restrained proliferation and impaired colony formation. Furthermore, TGFB2-AS1 depletion remarkably promoted the apoptosis of HepG2 cells and inhibited migration and invasion. |
| Pubmed ID | 31066006 |
| Year | 2019 |
| Title | Down-regulation Expression of TGFB2-AS1 Inhibits the Proliferation, Migration, Invasion and Induces Apoptosis in HepG2 Cells |
External Links
| Links for TGFB2-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |