Basic Information
| LncRNA/CircRNA Name | THOR |
| Synonyms | Lnc-THOR, ENSG00000226856 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, RIP, Western blot |
| Sample | retinoblastoma tissues, cell lines (WERI-Rb1, Y79, ARPE-19) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA THOR was over-expressed in the retina tissues from retinoblastoma patients and retinoblastoma Y79 and WERI-Rb1 cell lines. Knockdown of lncRNA THOR inhibits cell growth, migration and promotes cell apoptosis in retinoblastoma Y79 cells. |
| Pubmed ID | 30119193 |
| Year | 2018 |
| Title | LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein. |
External Links
| Links for THOR | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |