Basic Information
| LncRNA/CircRNA Name | CASC11 |
| Synonyms | NA |
| Region | GRCh38_8:127686343-127733967 |
| Ensemble | ENSG00000249375 |
| Refseq | NR_117101 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | glioma and control normal tissues ,Glioma cells (U87, U251, T98 G, SHG44) |
| Expression Pattern | up-regulated |
| Function Description | CASC11 was significantly up-regulated in the glioma specimens and cells, and the ectopic overexpression indicated the poor prognosis of glioma patients.CASC11 expression could be activated by the transcription factor SP1.Knockdown of CASC11 impaired the proliferation, migration and tumor growth of glioma cells.miR-498 was found to target the 3'-UTR of lncRNA CASC11 and FOXK1 mRNA. |
| Pubmed ID | 31121483 |
| Year | 2019 |
| Title | SP1 Induced lncRNA CASC11 Accelerates the Glioma Tumorigenesis Through Targeting FOXK1 via Sponging miR-498 |
External Links
| Links for CASC11 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |