Basic Information
| LncRNA/CircRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP etc. |
| Sample | cell lines (A549, H322, H460, GLC-82, SPC-A1), lung cancer tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | INCR overexpression suppressed proliferation and invasion in lung cancer cells.TINCR was confirmed as a molecular sponge of miR-544a. We further validated that miR-544a facilitated proliferation and invasion, and miR-544a could reverse TINCR-mediated anti-proliferation and anti-invasion effect in lung cancer cells. TINCR acted as a competing endogenous RNA (ceRNA) to sequester miR-544a from its target gene FBXW7. FBXW7 suppressed proliferation and invasion,and FBXW7 knockdown abolished the inhibition of TINCR on proliferation and invasion in lung cancer cells. |
| Pubmed ID | 29324317 |
| Year | 2018 |
| Title | TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer. |
External Links
| Links for TINCR | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |