Basic Information
| LncRNA/CircRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, RNAi, RIP etc. |
| Sample | cell lines (MRC-5, PC9, H1299, H522, A549, 95D,95C and H2172), 293T cell,NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | TINCR can interact with BRAF to facilitate its kinase activity, thereby leading to activation of oncogenic mitogen-activated protein kinase (MAPK) pathway. |
| Pubmed ID | 29427662 |
| Year | 2018 |
| Title | TINCR facilitates non-small cell lung cancer progression through BRAF-activated MAPK pathway. |
External Links
| Links for TINCR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |