Basic Information
| LncRNA/CircRNA Name | TMPO-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:98512973-98516422 |
| Ensemble | ENSG00000257167 |
| Refseq | NR_027157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR, Western blot |
| Sample | GC tissues,cell lines (HGC-27, SGC-7901, BGC-823 and AGS) |
| Expression Pattern | up-regulated |
| Function Description | Functionally, gain- and loss-of-function studies showed that TMPO-AS1 overexpression enhanced the proliferation, migration, invasion and EMT of GC cells in vitro, whereas knockdown of TMPO-AS1 inhibited these malignant traits. TMPO-AS1 could function as a competing endogenous RNA (ceRNA) by sponging miR-140-5p in GC cells, thereby diminishing the inhibition on SOX4, an EMT regulator. |
| Pubmed ID | 32110100 |
| Year | 2020 |
| Title | Long Non-Coding RNA TMPO-AS1 Promotes Cell Migration and Invasion by Sponging miR-140-5p and Inducing SOX4-Mediated EMT in Gastric Cancer |
External Links
| Links for TMPO-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |