Basic Information
| LncRNA/CircRNA Name | TMPO-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:98512973-98516422 |
| Ensemble | ENSG00000257167 |
| Refseq | NR_027157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) tissues, Cervical cancer cell lines HeLa, C33a, SiHa, HCC94 and the normal cervical epithelial cell line End1/E6E7 |
| Expression Pattern | up-regulated |
| Function Description | TMPO-AS1 was highly expressed in CC. Besides, TMPO-AS1 knockdown inhibited proliferation and migration, and induced apoptosis. TMPO-AS1 located in cytoplasm and it promoted RAB14 expression by absorbing miR-577. RAB14 overexpression or miR-577 knockdown restored the suppressing effect of TMPO-AS1 knockdown on the biological behavior of CC cells |
| Pubmed ID | 31483914 |
| Year | 2019 |
| Title | TMPO-AS1 promotes cervical cancer progression by upregulating RAB14 via sponging miR-577 |
External Links
| Links for TMPO-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |