Basic Information
| LncRNA/CircRNA Name | TNK2-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:195908076-195911257 |
| Ensemble | ENSG00000224614 |
| Refseq | NR_145450 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RIP, qPCR, other |
| Sample | NSCLC tissues and cell lines (A549, 95C, 95D, H1299, H838 and H2291) |
| Expression Pattern | up-regulated |
| Function Description | We found that TNK2-AS1 could increase viability and migration of NSCLC cells in vitro. TNK2-AS1 also promoted NSCLC xenograft tumor growth and metastasis in vivo. TNK2-AS1 could interact with STAT3 to increase its protein stability by protecting it from proteasome-mediated degradation. STAT3 could also bind TNK2-AS1 promoter to trigger its transcription. The positive feedback loop between STAT3 and TNK2-AS1 therefore augmented STAT3 signaling by elevating VEGFA expression to facilitate angiogenesis. |
| Pubmed ID | 30454892 |
| Year | 2018 |
| Title | The Positive Feedback Between lncRNA TNK2-AS1 and STAT3 Enhances Angiogenesis in Non-Small Cell Lung Cancer |
External Links
| Links for TNK2-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |