Basic Information
| LncRNA/CircRNA Name | TNRC6C-AS1 |
| Synonyms | trinucleotide repeat containing 6C-AS1 |
| Region | GRCh38_17:78107398-78111799 |
| Ensemble | ENSG00000204282 |
| Refseq | NR_040071 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | RIP, RT-qPCR, Western blot analysis |
| Sample | TC tissues,TC cell lines BCPAP (number BNCC338685), TPC-1 (number BNCC337912), K1 (number BNCC337627), SW579 (number BNCC100182), FTC-133 (number BNCC33799) and normal thyroid cell line Nthy-ori 3-1 (number BNCC340487) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA TNRC6C-AS1 was highly expressed while STK4 was poorly expressed in TC tissues. LncRNA TNRC6C-AS1 promoted the STK4 methylation and down-regulated STK4 expression, which further activated the Hippo signalling pathway.TNRC6C-AS1 increases STK4 promoter methylation to down-regulate STK4 expression, thereby promoting the development of TC through activation of Hippo signalling pathway. |
| Pubmed ID | 31657132 |
| Year | 2020 |
| Title | Long Non-Coding RNA TNRC6C-AS1 Promotes Methylation of STK4 to Inhibit Thyroid Carcinoma Cell Apoptosis and Autophagy via Hippo Signalling Pathway |
External Links
| Links for TNRC6C-AS1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |