Basic Information
| LncRNA/CircRNA Name | TNRC6C-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:78107398-78111799 |
| Ensemble | ENSG00000204282 |
| Refseq | NR_040071 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot, luciferase reporter assay, etc. |
| Sample | human TC cell lines (ARO, Hth74), differentiated TC cell line (FTC-133), normal human thyroid cell line (HTori3). Human specimens (36 pairs of TC tissues and matched adjacent tissues). |
| Expression Pattern | down-regulated |
| Function Description | LncRNA TNRC6C-AS1 and UNC5B were overexpressed while miR-129-5p was downregulated in TC. TNRC6C-AS1 could competitively bind to miR-129-5p as a ceRNA and upregulate the expression of UNC5B, a target gene of miR- 129-5p. Therefore, the downregulation of TNRC6C-AS1 could silence UNC5B, thus suppress TC development. |
| Pubmed ID | 29893424 |
| Year | 2018 |
| Title | LncRNA TNRC6C-AS1 regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p. |
External Links
| Links for TNRC6C-AS1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |