Basic Information
| LncRNA/CircRNA Name | TOB1-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:50866679-50909737 |
| Ensemble | ENSG00000229980 |
| Refseq | NR_038458 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | GC tissues,cell lines (AGS and MKN74) |
| Expression Pattern | down-regulated |
| Function Description | The levels of TOB1-AS1 were decreased in GC tissues and cell lines. Either TOB1-AS1 or NEU1 upregulation accelerated GC cell apoptosis, hampered proliferation, migration, and invasion. Further, the role of TOB1-AS1 silencing on cell behaviors was abrogated by NEU1 upregulation. TOB1-AS1 and NEU1 exerted their roles via Wnt/b-catenin signaling pathway. Overexpression of TOB1-AS1 blocked GC development in vivo. Mechanically, miR-23a was targeted by TOB1-AS1, but directly targeted NEU1. |
| Pubmed ID | 31799657 |
| Year | 2019 |
| Title | Long Non-Coding RNA TOB1-AS1 Modulates Cell Proliferation, Apoptosis, Migration and Invasion Through miR-23a/NEU1 Axis via Wnt/b-catenin Pathway in Gastric Cancer |
External Links
| Links for TOB1-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |