Basic Information
| LncRNA/CircRNA Name | TONSL-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:144437675-144439971 |
| Ensemble | ENSG00000232600 |
| Refseq | NR_109770 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot assay etc. |
| Sample | gastric cancer tissues and their adjacent normal tissues ,human gastric cancer cell lines (SGC-7901, MGC-803) |
| Expression Pattern | down-regulated |
| Function Description | TONSL-AS1 was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803 cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo.TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. |
| Pubmed ID | 31158361 |
| Year | 2019 |
| Title | A Novel Long Non-Coding RNA TONSL-AS1 Regulates Progression of Gastric Cancer via Activating TONSL |
External Links
| Links for TONSL-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |