Basic Information
| LncRNA/CircRNA Name | TP73-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000227372 |
| Refseq | NR_033708 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, RIP, Dual luciferase reporter assay, Western blot |
| Sample | Cervical cancer tissue samples,cervical endothelial cells (NCEC) cultured from normal cervical surgical tissue. Cell lines included human embryonic kidney epithelial cells HEK293 (CRL-1573), human cervical cancer cell lines HeLa (CCL-2), SiHa (HTB-35), CASKI (CRM-CRL-1550) and C-33A (HTB-31) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA TP73-AS1 was overexpressed in cervical cancer tissues and cells and was associated with reduced expression of miR-329-3p. Down-regulation of lncRNA TP73-AS1 inhibited cell proliferation, migration and invasion and increased miR-329-3p expression.LncRNA TP73-AS1 knockdown resulted in miR-329-3p silencing. In tumor xenografts, expression of TP73-AS1 reduced the tumor volume and down-regulated the expression levels of the SMAD2 gene. |
| Pubmed ID | 31663517 |
| Year | 2019 |
| Title | Long Noncoding RNA TP73-AS1 Targets MicroRNA-329-3p to Regulate Expression of the SMAD2 Gene in Human Cervical Cancer Tissue and Cell Lines |
External Links
| Links for TP73-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |