Basic Information
| LncRNA/CircRNA Name | TPT1-AS1 |
| Synonyms | NA |
| Region | GRCh38_13:45341345-45393413 |
| Ensemble | ENSG00000170919 |
| Refseq | NR_024458 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot |
| Sample | cervical cancer tissues, cell lines (C33A, SiHa, HeLa, CaSki, ME-180, NC104) |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated for the first time that TPT1-AS1 expression was up-regulated in CC tissues and cell lines. High TPT1-AS1 was significantly correlated with adverse prognostic characteristics and poor survival. TPT1-AS1 overexpression and knockdown experiments revealed that TPT1-AS1 promoted cell colony formation, proliferation, migration, invasion and EMT progression of CC cells in vitro and in vivo. The underlying mechanism indicated that TPT1-AS1 functioned as an endogenous sponge for miR-324-5p in CC cells. |
| Pubmed ID | 30045766 |
| Year | 2018 |
| Title | Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p. |
External Links
| Links for TPT1-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |