Basic Information
| LncRNA/CircRNA Name | TPTEP1 |
| Synonyms | lncRNA-TPTE pseudogene 1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | Human NSCLC tumors and matched normal tissues, cell lines (A549 and NCI-H1299,BEAS-2B) |
| Expression Pattern | down-regulated |
| Function Description | In the present study, significant downregulation of TPTEP1 in tumors compared with normal tissues from patients with NSCLC was observed. Using a dual-luciferase reporter assay and western blot analysis, it was further validated that TPTEP1 sponged miR-328-5p to upregulate Src kinase signaling inhibitor 1 (SRCIN1) in NSCLC cells. Through regulation of SRCIN1, TPTEP1 was indicated to inactivate the Src and STAT3 pathways in NSCLC cells. |
| Pubmed ID | 32323798 |
| Year | 2020 |
| Title | lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells |
External Links
| Links for TPTEP1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |