Basic Information
| LncRNA/CircRNA Name | TRHDE-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:72253508-72274907 |
| Ensemble | ENSG00000236333 |
| Refseq | NR_026836 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Luciferase reporter assay , Western blot etc. |
| Sample | Lung cancer tissues and normal tissues ,cell lines(A549 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | TRHDE-AS1 is mainly located in the cytoplasm and that the cell proliferation and invasion were suppressed in the group of overexpressed TRHDE-AS1.miR-103 could directly bind to TRHDE-AS1 and provided evidence of the oncogenic function of miR-103. Besides, we proved that miR-103 exerted its function by adjusting the expression level of the tumor-suppressor gene KLF4, and the expression level was negatively associated with miR-103. |
| Pubmed ID | 31119790 |
| Year | 2019 |
| Title | Overexpression of the Long Noncoding RNA TRHDE-AS1 Inhibits the Progression of Lung Cancer via the miRNA-103/KLF4 Axis |
External Links
| Links for TRHDE-AS1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |