Basic Information
| LncRNA/CircRNA Name | TRPM2-AS |
| Synonyms | transient receptor potential cation channel subfamily M member 2 antisense RNA |
| Region | GRCh38_21:44414588-44425272 |
| Ensemble | ENSG00000230061 |
| Refseq | NR_109964 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-qPCR, Western blot, RIP |
| Sample | CRC cells (LoVo, HCT116, SW480, SW620) and human normal colorectal mucosal cell (FHC) |
| Expression Pattern | up-regulated |
| Function Description | TRPM2-AS was significantly upregulated in CRC cells. Knock-down of TRPM2-AS inhibited CRC cell proliferation. TRPM2-AS directly interacted with RNA-binding protein (RBP) TAF15 and thus maintained the mRNA stability of TRPM2. |
| Pubmed ID | 31887411 |
| Year | 2020 |
| Title | TRPM2-AS Promotes Cancer Cell Proliferation Through Control of TAF15 |
External Links
| Links for TRPM2-AS | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |