Basic Information
| LncRNA/CircRNA Name | TRPM2-AS |
| Synonyms | NA |
| Region | GRCh38_21:44414588-44425272 |
| Ensemble | ENSG00000230061 |
| Refseq | NR_109964 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | GC cell lines(SGC-7901, MGC-803, SNU-601, and BGC-823?? and gastric epithelium cell, GES-1 |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of TRPM2-AS were increased in both GC tissues and cell lines. We also showed that overexpression of TRPM2-AS was modulated by ELK1, a transcription factor. Higher expressions of TRPM2-AS were significantly related with invasion depth, TNM stage, lymphatic metastasis, and shorter overall survival. TRPM2-AS expression was an independent prognostic factor in patients with GC.Depression of TRPM2-AS suppressed proliferation, migration, and invasion in GC cells.TRPM2-AS directly inhibited miR-195, which targeted the 3'-untranslated region of high-mobility group AT-hook 1 (HMGA1) messenger RNA. |
| Pubmed ID | 31104318 |
| Year | 2019 |
| Title | ELK1-induced upregulation of lncRNA TRPM2-AS promotes tumor progression in gastric cancer by regulating miR-195/ HMGA1 axis |
External Links
| Links for TRPM2-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |