Basic Information
| LncRNA/CircRNA Name | TRPM2-AS |
| Synonyms | TRPM2-AS, TRPM2-AS1 |
| Region | GRCh38_21:44414588-44425272 |
| Ensemble | ENSG00000230061 |
| Refseq | NR_109964 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Microarray, qPCR etc. |
| Sample | cell line (PC3) |
| Expression Pattern | differential expression |
| Function Description | This essential role, coupled to the TRPM2-AS low-expression levels in healthy tissues, makes this ncRNA a suitable therapeutic target for further clinical studies. To get insights into the survival mechanism controlled by this molecule, we ablated its expression in prostate cancer cells and performed a genome-wide analysis of the transcripts differentially regulated in dying cells. |
| Pubmed ID | 26484139 |
| Year | 2014 |
| Title | Expression-profiling of apoptosis induced by ablation of the long ncRNA TRPM2-AS in prostate cancer cell. |
External Links
| Links for TRPM2-AS | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |