Basic Information
| LncRNA/CircRNA Name | TSLC1-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | glioma tissues, cell lines (U87, U251, SNB-19 etc.) |
| Expression Pattern | down-regulated |
| Function Description | The data showed that TSLC1-AS1 expression was down-regulated in tumor tissues compared with that in adjacent normal tissues, and negatively associated with the WHO criteria of the tumors. Overexpression of TSLC1-AS1 resulted in up-regulation of TSLC1 and significant inhibition of cell proliferation, migration and invasion in U87 cells, while knockdown of TSLC1-AS1 in SNB-19 cells showed the opposite effetc. The expression of TSLC1-AS1 was also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF. |
| Pubmed ID | 25031725 |
| Year | 2014 |
| Title | LncRNA TSLC1-AS1 is a novel tumor suppressor in glioma. |
External Links
| Links for TSLC1-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |