Basic Information
| LncRNA/CircRNA Name | TSlnc8 |
| Synonyms | NA |
| Region | GRCh38_8:29673922-29748109 |
| Ensemble | ENSG00000251191 |
| Refseq | NR_026765 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | human lung cancer cell lines (A549, H441 ,and H1975) and normal human bronchial epithelial cell line HBE (CVCL_0287) |
| Expression Pattern | down-regulated |
| Function Description | TSLNC8 was significantly downregulated in lung cancer cells compared to normal bronchial epithelial cells.Overexpression of TSLNC8 in A549 cells significantly inhibited proliferation in a time-dependent manner and promoted cell apoptosis. TSLNC8 overexpression suppressed cell migration and invasion, and upregulation of TSLNC8 regulated the protein levels of Beclin-1, p62, ATG14, and LC3-II and inhibited the IL-6/STAT3/HIF-1alpha signaling pathway. |
| Pubmed ID | 31601776 |
| Year | 2019 |
| Title | Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1?) Signaling Pathway in Non-Small Cell Lung Cancer |
External Links
| Links for TSlnc8 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |