Basic Information
| LncRNA/CircRNA Name | TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 |
| Ensemble | ENSG00000237298 |
| Refseq | NR_038272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Luciferase assay, RIP |
| Sample | BC tissues,cell lines (MCF-7, LCC9, T-47D, SKBR3,MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | TTN-AS1 expression level in BC samples was higher than that of adjacent tissue. Besides, the ability of cell migration and invasion of BC cells was inhibited after TTN-AS1 was silenced, while cell migration and cell invasion of BC cells were promoted after TTN-AS1 was overexpressed. In addition, miR-140-5p was upregulated after silencing of TTN-AS1 in BC cells, while miR-140-5p was downregulated after overexpression of TTN-AS1 in BC cells. |
| Pubmed ID | 31966055 |
| Year | 2020 |
| Title | Long non-coding RNA TTN-AS1 promotes breast cancer cell migration and invasion via sponging miR-140-5p |
External Links
| Links for TTN-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |