Basic Information
| LncRNA/CircRNA Name | TTTY15 |
| Synonyms | NA |
| Region | GRCh38_Y:12662334-12692233 |
| Ensemble | ENSG00000233864 |
| Refseq | NR_001545 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | PCa tumour tissues, normal prostate cell line RWPE1,PCa cell lines (DU145, LNCaP, PC3, 22RV1, and C42B) |
| Expression Pattern | up-regulated |
| Function Description | In most patients with PCa, TTTY15 was the most elevated lncRNA located on the Y chromosome. Knockout of this lncRNA by two different CRISPRCas9 strategies suppressed PCa cell growth both in vitro and in vivo. TTTY15 promoted PCa by sponging the microRNA let-7, consequently increasing CDK6 and FN1 expression. FOXA1 is an upstream regulatory factor of TTTY15 transcription |
| Pubmed ID | 30527798 |
| Year | 2018 |
| Title | The Long Noncoding RNA TTTY15, Which Is Located on the Y Chromosome, Promotes Prostate Cancer Progression by Sponging let-7 |
External Links
| Links for TTTY15 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |