Basic Information
| LncRNA/CircRNA Name | TUC338 |
| Synonyms | NA |
| Region | GRCh38_12:53464468-53465057 |
| Ensemble | ENSG00000282977 |
| Refseq | NR_109828 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Luciferase reporter assay, Microarray, Western blot, qPCR, etc. |
| Sample | HCC cell lines. |
| Expression Pattern | up-regulated |
| Function Description | These results showing the pervasive genomic nature of TUC338 RNA occupancy emphasize a broad role in gene regulation. More specifically, there is evidence that direct physical interactions between TUC338 RNA and PAI-RBP1 resulting in post-transcriptional regulation of PAI-1 mRNA could contribute, in part, to the oncogenic effects of enhanced TUC338 expression that is observed in HCC. |
| Pubmed ID | 29888750 |
| Year | 2018 |
| Title | Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma. |
External Links
| Links for TUC338 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |