Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | taurine-upregulated gene 1 |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | Dual luciferase reporter assay, Western blot analysis, RT-qPCR |
| Sample | colon cancer cell lines (SW620, HT-29, CaCo-2) and normal human colon fibroblast (CCD-18Co) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 expression was up-regulated in CaCO-2, SW620 and HT-29 cells, while miR-26a-5p was down-regulated.the overexpression of TUG1 significantly up-regulated the levels of MMP-14, VEGF, p-p38 mitogen-activated protein kinase (p-p38 MAPK) and p-HSP27 (heat shock protein 27), and promoted the proliferation, invasion and EMT of Cc cells. |
| Pubmed ID | 31697952 |
| Year | 2019 |
| Title | Taurine Up-Regulated 1 Accelerates Tumorigenesis of Colon Cancer by Regulating miR-26a-5p/MMP14/p38 MAPK/Hsp27 Axis in Vitro and in Vivo |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |