Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | NA |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | CRC tumor tissues and corresponding adjacent benign tissues,CRC cell lines (HCT116, HT29 and SW480) and normal human colon mucosal epithelial cell line NCM460 |
| Expression Pattern | up-regulated |
| Function Description | The over-expression of TUG1 and down-regulation of miR-153-1 in CRC. Knockdown of TUG1 or ectopic over-expression of miR-153-1 in SW480 significantly suppressed cell proliferation, migration and viability. TUG1 negatively modulated miR-153-1 expression, and simultaneous expression of TUG1 completely abolished the anti-tumor effect of miR-153-1. KLF4 as a transcription factor of miR-153-1, which was negatively regulated by TUG1 along with EZH2. |
| Pubmed ID | 31576172 |
| Year | 2019 |
| Title | Long Non-Coding RNA TUG1-mediated Down-Regulation of KLF4 Contributes to Metastasis and the Epithelial-To-Mesenchymal Transition of Colorectal Cancer by miR-153-1 |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |