Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | NA |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Dual luciferase reporter assay |
| Sample | breast cancer tissues, cell lines (MCF7, T47D, MCF10 A, MDA-MB-231, BT549) |
| Expression Pattern | down-regulated |
| Function Description | we observed a significant decrease of TUG1 in tumor tissues compared to the normal tissues. very low concentration of cisplatin caused cell proliferation inhibition in TUG1-overexpressed-TNBC cells. Sponging of TUG1 to miR-197 was proved by a dual luciferase reporter assay. Sponging of TUG1 to miR-197 was proved by a dual luciferase reporter assay. |
| Pubmed ID | 30098551 |
| Year | 2018 |
| Title | Long non-coding RNA TUG1 sponges miR-197 to enhance cisplatin sensitivity in triple negative breast cancer. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |